I put my $.02 in a while ago, but I am glad to see these responses. Somehow, I expected to see more of a response from "the other side". Once upon a time, I had a few devenomized snakes. I even used them in some educational programs (such as when I guest lectured for the Herpetology class at a local university - including a "lab" on how to work with venomous snakes. I demonstrated techniques for safely manipulating a variety of cobras, rattlesnakes, gilas, etc., including the use of tongs and hooks.) There was just no way I was going to let students I didn't know practice catching, manipulating, or containing techniques on real hots. One could argue that a kingsnake or other nonvenomous snake could have been substituted, but it certainly wouldn't have been realistic. Nothing behaves quite so much like a pi$$ed off rattlesnake as a pi$$ed off rattlesnake.
Anyway, I prefer my hots intact. Its just the way they are supposed to be. Not to come off as an adrenaline junkie or thrill seeker; but it just isn't the same when they can't fight back, so to speak. The end result is carelessness in handling, shortcuts, and unnecessary risk. (Yes, I know someone that was nearly killed by a 'void)
As to the hypothetical scenario posed (a harmless, effective, permanent way to cause the "disappearance or deactivation" of venom) - If I wanted a cornsnake, I would buy a cornsnake. When I want a cobra (rattlesnake, whatever), the same rule applies: This is what it is...if it isn't what you want, or you don't have the skills and knowledge to deal with it, DON'T BUY IT.