'Game-changing' gene edit turned this anole lizard into an albino - FaunaClassifieds
 Sponsors »  Breeders | Dealers |  Importers/Exporters | Caging | Feed | Supplies | Services | Events 
  Inside FaunaClassifieds » Product Reviews |  Classifieds!   | Photo Gallery   | Banner Advertising 
  Want to help keep this site alive? Click here.

Go Back   FaunaClassifieds > Reptile & Amphibian - General Discussion Forums > Herps In The News


Herps In The News Local or national articles where reptiles or amphibians have made it into the news media. Please cite sources.

Thread Tools Display Modes
Old 04-03-2019, 10:55 PM   #1
'Game-changing' gene edit turned this anole lizard into an albino

Very interesting. I think it would be awesome if these techniques could help save species on the brink of extinction, or to alter the underlying composition of a snake's venom so that it could then be compounded into new life-saving drugs.


'Game-changing' gene edit turned this anole lizard into an albino

By Jon Cohen Apr. 1, 2019, 4:45 PM

The mighty genome editor CRISPR isn’t so powerful in lizards and snakes: Never before has it been used to edit the embryos of these reptiles. Now, researchers have come up with a workaround—by editing the immature, unfertilized eggs of brown anole lizards.

Researchers typically edit with CRISPR by injecting it into a single-celled fertilized egg, creating a DNA change that is present in all subsequent cells. But female anoles are a special challenge: They store sperm in their oviducts for long periods, making it difficult to time the introduction of CRISPR to fertilization. They also form eggshells at fertilization, and it’s extremely difficult to insert a needle at that stage without damaging the embryo.

So researchers from the University of Georgia (UGA) in Athens instead injected the CRISPR complex into immature eggs still in the ovaries, targeting a gene that produces tyrosinase, an enzyme that affects pigmentation. After altering 146 immature eggs from 21 lizards, the scientists got their payoff: four albino offspring, they report in a preprint posted this week on bioRxiv. To produce the change in coloration, both maternal and paternal genes must have mutated, making the researchers suspect that CRISPR edited the egg genes and then stuck around, crippling the paternal genes after fertilization.

The new technique, which the scientists say will likely work in many other lizard and snake species, “is a game changer,” tweeted Tony Gamble, an evolutionary biologist who studies geckos at Marquette University in Milwaukee, Wisconsin. UGA’s Douglas Menke, the mouse developmental geneticist who led the experiment, was more to the point: “The whole field of developmental genetics has left reptiles in the dust.” Until now.
Old 04-04-2019, 12:33 AM   #2
Hmm, I can't wait for them to combine this technology with AI.
Old 04-04-2019, 04:15 AM   #3
This is interesting news for me. Thank you.
Old 04-11-2019, 07:05 PM   #4
Great article, thanks Melinda.

Join now to reply to this thread or open new ones for your questions & comments! FaunaClassifieds.com is the largest online community about Reptile & Amphibians, Snakes, Lizards and number one classifieds service with thousands of ads to look for. Registration is open to everyone and FREE. Click Here to Register!


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Similar Threads
Thread Thread Starter Forum Replies Last Post
[Wanted] End of Game, ALBINO RED EAR SLIDER TURTLES HATCHLINGS, Paying $380/each, Any Quantity sunshinestatereptiles Turtles/Tortoises 31 05-31-2014 02:19 PM
Green Anole Intelligence: Researchers Shocked by Lizard Brainpower zookeeperfrank Other Lizards Discussion Forum 0 06-03-2013 11:57 PM
First lizard genome sequenced: Green anole lizard's genome sheds light on vertebrate RSS_news Herps In The News 0 08-31-2011 04:20 PM

All times are GMT -4. The time now is 12:27 PM.

Ebates Coupons and Cash Back

Fauna Top Sites

Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.
Page generated in 0.03558707 seconds with 10 queries
Content copyrighted ©2002-2018, FaunaClassifieds, LLC