Snake stem cells used to create venom-producing organoids - FaunaClassifieds
FaunaClassifieds  
 Sponsors   Breeders | Dealers |  Importers/Exporters | Caging | Feed | Supplies | Services | Events 
  Inside FaunaClassifieds  Product Reviews |  Classifieds!   | Photo Gallery   | Banner Advertising 
 
  Do you want to be able to bump and highlight your classified ads? Click here!

Go Back   FaunaClassifieds > Reptile & Amphibian - General Discussion Forums > Herps In The News

Notices

Herps In The News Local or national articles where reptiles or amphibians have made it into the news media. Please cite sources.

Reply
 
Thread Tools Display Modes
Old 02-02-2020, 06:41 PM   #1
JColt
Snake stem cells used to create venom-producing organoids

Organoids have become an important tool for studying many disease processes and testing potential drugs. Now, they are being used in a surprising and unexpected way: for the production of snake venom. On January 23 in the journal Cell, researchers are reporting that they have created organoids of the venom glands of the Cape coral snake (Aspidelaps lubricus cowlesi) and that these glands are capable of producing venom.

"More than 100,000 people die from snake bites every year, mostly in developing countries. Yet the methods for manufacturing antivenom haven't changed since the 19th century," says senior author Hans Clevers of the Hubrecht Institute for Developmental Biology and Stem Cell Research at Utrecht University in the Netherlands. "It's clear there is a huge unmet medical need for new treatments."

He adds: "Every snake has dozens of different components in their venom. These are extremely potent molecules that are designed to stop prey from running away. They affect systems as varied as the brain, neuromuscular junctions, blood coagulation, and more. Many of them have potential bioprospecting applications for new drugs."

Clevers' lab traditionally focuses on organoids made from human and mouse cells. But some of his students decided to study stem cells and develop organoids from reptiles. "This is a field that does not exist, so they thought it was interesting to study the most iconic reptilian organ, the snake venom gland," he says. "Once we grew the venom glands as organoids, we realized that they make a lot of venom."

The investigators started with the Cape coral snake because they knew a breeder who was able to supply some fertilized eggs. The snakes were removed from the eggs before hatching, and small pieces of tissue were removed from various organs and placed into gels, along with growth factors. In addition to the venom glands, the researchers also made organoids of the snake liver, pancreas, and gut.

"It would have been difficult to isolate stem cells from these snakes because we don't know what they look like," Clevers explains. "But it turned out we didn't need to. The cells soon began dividing and forming structures." In fact, he says, the venom gland organoids grew so fast that in just one week, they were able to break them apart and re-plate them, generating hundreds of plates within two months. He notes that if it could be commercialized, this method would be much more efficient than the way venom is currently produced -- by raising snakes on farms and milking their glands.

The researchers were able to identify at least four distinct types of cells within the venom gland organoids. They confirmed that the venom peptides produced were biologically active and resembled the components of venom from live snakes.

A challenge of the work was determining gene-expression levels in the venom gland organoids. "The genomes of most snakes have not been annotated," Clevers says. The investigators were able to identify certain genes that were active under expansion conditions, suggesting that these pathways -- including most importantly the Wnt pathway -- may play a role in reptilian stem cell growth.

One of the collaborators on the study was Freek Vonk, a herpetologist and well-known Dutch television host who Clevers calls "the Steve Irwin of Holland." Vonk is affiliated with Leiden University and the Naturalis Biodiversity Center.

https://www.sciencedaily.com/release...0123152533.htm
 
Old 02-02-2020, 06:54 PM   #2
WebSlave
Hopefully someone won't try to incorporate this into a coronavirus and grow a pathogen with generates snake venom among with it's other pleasant attributes...
 
Old 02-02-2020, 10:05 PM   #3
E.Shell
Quote:
Originally Posted by WebSlave View Post
Hopefully someone won't try to incorporate this into a coronavirus and grow a pathogen with generates snake venom among with it's other pleasant attributes...
On it....
 

Join now to reply to this thread or open new ones for your questions & comments! FaunaClassifieds.com is the largest online community about Reptile & Amphibians, Snakes, Lizards and number one classifieds service with thousands of ads to look for. Registration is open to everyone and FREE. Click Here to Register!

 
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Similar Threads
Thread Thread Starter Forum Replies Last Post
[For Sale] Venom Defender Snake Gloves (L/XL) MCSnakes Venomous Snakes 0 04-23-2019 10:08 AM
Therapy with bone marrow-derived stem cells does not improve short-term recovery afte RSS_news Herps In The News 0 12-29-2012 12:00 PM
Mexican salamander helps uncover mysteries of stem cells and evolution RSS_news Herps In The News 0 07-11-2010 10:20 PM
Scientists First to Create Functional Inner-Ear Cells Southern Wolf General BS forum 1 05-17-2010 01:39 AM


All times are GMT -4. The time now is 01:31 PM.







TESTING!
Fauna Top Sites


Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
Page generated in 0.07576799 seconds with 12 queries
Content copyrighted 2002-2018, FaunaClassifieds, LLC