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It's passed around alot that there is a greater chance of impaction due to the density and structure of the hair...
And they might have a lot more hair than a rat or similarly sized rabbit, even the normal ones, but all this would do is delay the digestion a bit in most cases, if the guinea pig is appropriately sized as a prey item, it shouldn't really represent an impaction danger as far as I can see.
I've used them myself as feeder animals a few times, usually when other items were unavaliable or the guinea pigs were superabundant, fed 'em to a few burms, some good sized BCI and a 'tic with no problems at all.
The first time I tried it was with a good sized burm and a subadult guinea pig, ate it prekilled no problems at all, the defication was pretty normal looking although there was a bit more less digested hair than with a rat it was passed very easily. I found the guinea pigs to be pretty easy to prekill too, not inclined to bite, so you can simply give the neck a solid twist in an appropriate manner, head's bigger in proportion to the weight too, so the grip is more secure and the action cleaner.
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