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As a general rule I am opposed to cross breeding. Basically, you end up with offspring of pet store value and will probably end up dumping many of your young there.
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This is only because of the relatively primitive nature of the herp hobby, and the incredible natural variety of herp species.
In nearly all well-established pet communities, there is a lot of hybridization -- cats, dogs, rodents, and others.
Look at what is happening with "designer snakes", mostly Ball Pythons and Cornsnakes, and the "dwarf" crossbreeds in the Reticulated and Burmese Python lines. Boa crossbreeds are the next logical step in the popularization of herp-keeping. As long as they don't get released back into the wild (already a problem with other animals, but not too much as hybrids don't usually survive in the wild), then there isn't any real reason not to.
Many boas, particularly BCI, already crossbreed in the wild when possible (not usually possible for island sub-species; but not uncommon with regional mainland variants).