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Universal antivenom being tested at Duke could change snake bite treatment worldwide

This treatment won't be cheap. A 2018 study of Varespladib to treat coral snake venom in pigs - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265968/ - found an effective dosage of 1 mg per kg of patient body weight, so about 50 mg of Varespladib would be needed to treat an adult person.

Current pricing can be found from chemical supply stores. These are not drug makers, these stores sell to the makers, and of course there's going to be a ton of markup by the maker and then the retailer. Unless someone has an awesomely generous pharmacy/insurance plan or guaranteed low co-pays, I don't see a keeper being able to afford keeping a dose at home.

https://www.sigmaaldrich.com/US/en/product/sigma/sml1100

https://www.adooq.com/varespladib-methyl.html
 
I'm sure CroFab will find a way to make money off it also.
 
bcr229 said:
This treatment won't be cheap. A 2018 study of Varespladib to treat coral snake venom in pigs - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265968/ - found an effective dosage of 1 mg per kg of patient body weight, so about 50 mg of Varespladib would be needed to treat an adult person.

Current pricing can be found from chemical supply stores. These are not drug makers, these stores sell to the makers, and of course there's going to be a ton of markup by the maker and then the retailer. Unless someone has an awesomely generous pharmacy/insurance plan or guaranteed low co-pays, I don't see a keeper being able to afford keeping a dose at home.

https://www.sigmaaldrich.com/US/en/product/sigma/sml1100

https://www.adooq.com/varespladib-methyl.html
Click to expand...



Those are small-scale research samples at lower purity. They do not represent the cost of higher-purity API in a Drug Product manufactured at scale. It is completely disconnected. If you want to see another disconnected example (that might put one's mind at ease to a degree), look at a reference standard on Sigma for metformin hydrochloride (an inexpensive API in tablets commonly and inexpensively used as a first-line treatment for oral control of insulin resistance and Type-II diabetes mellitus) Mind you, I am not saying the drug will be inexpensive, but the pricing of research samples is not indicative of the cost of Drug Product due to undisclosed contributing factors in the background.
 
Good update on the topic. Couple key notes in the report:
Universal antivenin unlikely. Broader venom fraction antivenom likely.
Venom shortage – amount per snake – causes antivenom shortage.
Development of antibody – synthetic antivenom – to counter fraction(s) of venom would be a universal approach to minimizing envenomation effects.
Synthetic antivenom does not cause serum sickness.

In a related story, a taipan in Australia used for venom extraction was reported to have provided the largest amount of venom ever recovered. (Live Science July 18, 2024)

https://www.livescience.com/animals...-4D7A-8808-805AD1FAF709&utm_source=SmartBrief
 
I missed the results of last year's second clinical trial. To be most effective the treatment has to occur within five hours of the bite.

gh.bmj.com

Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial

Introduction Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2, is a nearly ubiquitous component of snake venoms. We conducted a phase II clinical trial to assess efficacy and safety of...
gh.bmj.com gh.bmj.com

Ophirex Publishes Varespladib Phase 2 Data in BMJ Global Health — Ophirex | Lifesaving Antidotes

www.ophirex.com www.ophirex.com
 
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