Working with acrylic
Having a glass company fabricate for you might be a bit more expensive, but it might work. There materials cut best with a table saw and an 80 tooth tripple chip blade. My best suggestion is to look around and find a carpenter that will help you as a favor/experiment. You could even buy a blade and that might provide an incentive for him or her to help.
The best glue to use is a free flowing acrylic glue. This stuff is like water. TAP sells a squeeze bottle with a syringe tip specially made as an applicator. The glue won't harm the materials this bottle is made out of.
A gallon of Weldon 16 is really a lot of glue!! Also, this glue is a bit thicker, but still really runny, and makes strings that have a tendancy to get on the panels making them unsightly.
First, let's cover the gluing technique. If you get a squeeze bottle with a syringe tip you can easily apply the glue, with a little practice. I would suggest practicing with water in the bottle, when you get that right you will feel much better about gluing and you won't run as much risk in ruining any panels. Fill the bottle 2/3 full with water. Holding the bottle upright, squeeze the bottle and force some of the air out through the syringe tip. While still squeezing the bottle, turn it upside down and stop squeezing. While the vaccuum is trying to pull air into the bottle, no water will come out of the tip. In such a manner, you can move the tip into the vacinity of the joint that you want to glue without dripping glue all over the acrylic panels. Again, I would practice this technique using water and two panels until you are comforatble that you can weld a clean joint without dripping all over the acrylic panels. Replace the water with Glue and you're ready to go, make sure everything is dry before introducing glue where there was water.
To assemble the panels, you want the bottom panel to reach all of the way to the outside of the cage and the sides and back to sit on top of the bottom. If the cage is rectangular I suggest that the back and the front are as long as the top and bottom, so that the ends of the cage sit inside of the back and the front. If you draw this out with paper and pencil I think it will make sense.
Place the bottom on a level surface and place the back panel where you want it to sit. Using the squeeze bottle technique described above, run a bead of glue (practice first with water!) along the joining edge of the panels. The liquid glue should wick between the panels and fill the microscopic voids between the bottom edge of the back panel and the top of the bottom panel. Hold these panels in place for a couple of minutes and they should be strong enough to stand while you work on the cage front panel. Just don't bump them, because they really aren't strong enough to move for about 30 minutes, and then move them very carefully becsaue they aren't fully welded for 24 hours.
Finish gluing up the sides to the bottom and to themselves, and then you can work on the lid. I use a one piece lid on hinges, and I use an acrylic hasp for a latch. I use #16 glue for these items, applied with a q-tip. I put some glue, which is quite a bit thicker than the liquid free flowing glue that I use on the panels, on some aluminum foil and apply it to the surfaces that I am gluing.
Hope this helps, I have made up about a dozen of these cages and find them very useful. I also use the acrylic to make tops for aquariums and use them for larger specimens, can't beat the price of tanks at Petco and places like that.
For ventilation, I cut slots using my table saw. I place the panels over the retracted saw blade and raise the blade up into the panel, creating an interior of the panel slot. I have tried drilling, but it is very slow and doesn't produce enough air flow. Another solution is to cut a piece out the the center of the lid and silicone a piece of screen into the hole, plastic screens are available which are less abrasive.
Hope this helps!
Val Campbell