contractually, they are not allowed to do that.
Please keep that in mind. Businesses such as labs are famous for sending bills, shaking the tree to see if money falls out.
contractually, they are not allowed to do that.
Please keep that in mind. Businesses such as labs are famous for sending bills, shaking the tree to see if money falls out.
Rich, make sure that the tablet is not enteric-coated or else you would be causing yourself a problem by breaking that coating.
6.1 List of excipients
Tablet Core:
Microcrystalline cellulose
Mannitol (E421)
Croscarmellose sodium
Hypromellose (E464)
Magnesium stearate
Film-Coat:
Lactose monohydrate
Hypromellose (E464)
Titanium dioxide (E171)
Triacetin (E1518)
Iron oxide red (E172) {only Efient 10 mg}
Iron oxide yellow (E172)
Talc
Some tablets of prasugrel have an enteric coating in order to have dissolution of the tablet and release of the drug occur in the intestine instead of the stomach. It could be for various reasons like bioavailability improvement, conversion efficiency to its more active metabolite occurring in the proper place (intestine and liver), and reduction of risks of things like gastric bleeding.
If a tablet has an enteric coating, you are not supposed to split or crush it. Is the tablet scored? If it is not scored, then it is not intended to be split and the active pharmaceutical ingredient is not guaranteed to be equally distributed throughout the tablet, in which case half of the tablet is less likely to contain half of the dosage, making dosing irregular and unpredictable. If it is scored and if it does not have an enteric coating (sometimes also referred to as a film coating, but it depends), then it should be able to be split.
No, the tablets are NOT scored.
I guess I need to contact my cardiologist and just tell him I want to have the dosage reduced and get the 5mg pills. This bruising I am getting is just not normal. I got this bruise on my left forearm on the 19th just by bracing my arm on part of the generator to get some leverage to remove the sparkplugs, and I STILL have that darn discoloration that makes me look like some sort of leper or something. Makes me scared to death to do anything because just what used to be an inconsequential bump against something is no longer inconsequential.
And these aren't just surface skin bruises, neither. These go right to the muscle, which really aches for quite a while. Something is just not RIGHT.
I agree, and 5 mg tablets are available.S
If a tablet has an enteric coating, you are not supposed to split or crush it. Is the tablet scored? If it is not scored, then it is not intended to be split and the active pharmaceutical ingredient is not guaranteed to be equally distributed throughout the tablet, in which case half of the tablet is less likely to contain half of the dosage, making dosing irregular and unpredictable.
This. For any medication changes, or changes to your treatment plan. Because of interactions, your cardiologist should be aware of all the medications you are takng and the dosage. In addition, please discuss with your cardiologist *any* changes to his/her prescription before the change is made. For instance, for many medications, a generic substitution of a medication does not make much of a difference. This is not always true of cardiac medications.I guess I need to contact my cardiologist .
The trouble with that is the drug might be doing nothing protective at all right now, as its intended delivery system is compromised.
If you're already using prasugrel or clopidogrel, take these precautions:
Call your doctor immediately if you notice any signs of excessive bleeding that can't be explained: severe, prolonged, or unusual bleeding; pink or brown urine; red or black stools; bruises or purple skin spots; and coughing up or vomiting blood or clots. But don't stop taking the medication without your doctor's OK.
Tell every doctor or dentist you see that you're taking the drug, especially if you're about to undergo an invasive procedure.
Use an electric razor or be extra careful when shaving.
Take prasugrel with particular caution if you're of Korean descent, because some research suggests that the drug may have a stronger effect.
If you're taking clopidogrel or a smaller than recommended dose of prasugrel, consider asking your doctor if you should be tested for adequate platelet inhibition.
Potential prasugrel users should know about another research observation: After four months, prasugrel users seemed to experience an increased risk of cancerous tumors than clopidogrel users. That may have occurred either by chance or because higher bleeding rates lead to more scrutiny and detection of cancer. The FDA did not include cancer among the risks listed in the package insert, though it briefly mentioned the possibility elsewhere. But it did order the manufacturer to continue work on another clinical trial, already under way, to assess the drug's cancer-causing potential.