RI's can be very serious - I would highly recommend going to the vet and getting a culture ASAP. I got hit with an RI in my collection last year and it effected 8 snakes total - 4 of which died despite mine and my vet's rigorous efforts to save them. 2 fully recovered and 2 are still fighting hard in quarantine. Thank goodness the rest of my collection is safe, but dealing with this really opened my eyes to how serious a little bacteria can be.
Before treating you need to know what you're treating against - but in the meantime, I would get a hold of some F10 and start nebulizing your snakes once or twice a day for 15-20 minutes each session. This stuff kicks butt, and is effective against a broad range of bacteria, viruses, spores and fungi. I got some from my vet, but some other Fauna members have bought it here:
My Safe Bird Store - F10
You mix 1ml F10 with 250ml water, which works as both a nebulizing solution and a cleaner you can spray on surfaces etc.
Antibiotics commonly used in a nebulizer are Amikacin and Ceftazidime - but again, it is important to know what you're fighting before you start using antibiotics (especially antibiotics like Amikacin and Baytril, which are taxing on a snake's system as it is). Ceftazidime is a great antibiotic that is safe to use and has a broad spectrum, if you have to do a shot-gun treatment I would recommend it since not much resistance has built up against it and it doesn't hurt the snakes. It however is not effective against everything, so a culture is still a must. (Besides, why wouldn't you want to know what you're dealing with? If nothing else, the information could help someone in the future.) Many breeders swear by Tylosin which can be bought at most farm stores under the name Tylan-50 or Tylan-200 (different strengths) but it did not work for my situation. It is effective against Mycoplasma and a limited range of gram negative and positive bacterias but doesn't cure everything. Any other antibiotics I mentioned you will need a prescription for.
In the long run, waiting it out will just cause you more heartbreak and financial loss if it ends up being a nasty strain. Some RI's have been cured just by bumping temps up but I do not recommend waiting around and seeing, because it can be something bad and turn into deep-seeded pneumonia in a matter of days and result in the death of your snakes.
Make sure you aren't using any tools from your healthy collection with the sick snakes - wash hands and change clothes after dealing with the sick snakes. My RI started with 2 snakes in my collection that were previously healthy but came down with it due to spilling a water bowl when my AC was cranked and they got chilled. I didn't notice they were sick until I contaminated a few other snakes, since symptoms don't usually become visible until 1-2 weeks after contamination. Good on you for getting the sick ones moved into quarantine, but do monitor your other snakes closely for a period of time before doing any pairings or selling.
Good luck with them, and keep us posted
