Just so people can read....
This is a document by Dr. Elliot Jacobson That Toni's Vet Was/Is working with. I find it interesting. As should others.
http://www.reptilechannel.com/media/reptile-health/snake-health/inclusion-body-disease.aspx.pdf
Quoted From Text:
"
Snake Inclusion Body Disease
Research from the nation’s top snake inclusion body disease expert.
Text and photos by Elliott Jacobson, Ph.D., DVM, DACZM
Click images to enlarge
This boa constrictor with IBD has skin lesions. Remember, such signs can be indicative of other diseases, too.
A vet performs a liver biopsy on a boa using ultrasound-guided biopsy methods. Tissue biopsies are one way vets can
diagnose whether a snake has IBD.Soon after arriving at the University of Florida in 1977, I started receiving certain boid
snakes, Burmese pythons (Python molurus bivitattus) and boa constrictors (Boa constrictor), with signs of a neurological
disease. It was characterized by the formation of inclusions, unique stainable bodies, in the cytoplasm of a wide variety of
cells, including those in the central nervous system and circulating blood cells. Eventually it was named inclusion body
disease. Thereafter, IBD was seen in other boa and python species, and the green anaconda (Eunectes murinus). An
unconfirmed disease resembling IBD also was diagnosed in an eastern kingsnake (Lampropeltis g. getula) housed with boa
constrictors and in palm vipers (Bothriechis marchi). It’s unknown how many snakes die from IBD every year.
Reflecting on my 31 years studying IBD, what is most interesting to me is that in the early years I saw more cases of the
disease in Burmese pythons than in boa constrictors, but now it is the opposite. Speculation as to the reason for this change
abounds, but because good before-death tests aren’t available for IBD, we do not have the tools to sort out the factors of
this puzzle.
Clinical Signs
Although some snakes die within several weeks of showing the first signs of illness, others can remain alive for months or
more. For Burmese pythons, the most common signs of IBD are head tilts, abnormalities in body positioning, locomotor
abnormalities, “stargazing” and heads arching over bodies. Several pythons also lost muscle tone throughout their entire
bodies. In addition to signs of nervous system disease, IBD-affected boa constrictors and other related boas commonly
regurgitate food items within several days of eating. Regurgitation was not seen in Burmese pythons. Additional signs seen
in affected boas include oral inflammations, pneumonia and various tumors. Remember that the clinical signs seen in
snakes with IBD can be quite similar to signs of other snake diseases. Signs alone do not allow someone to make a specific
diagnosis.
I know from experience that certain boid snakes can have what we call a “subclinical infection.” In these infections an animal
is infected with a pathogen, but it does not manifest clinical signs of illness. Such animals may be very difficult to diagnose,
and they may spread the pathogen to other animals. Perhaps there are different disease-causing strains of the causative
agent, which may account for differences in the clinical appearance of infected snakes.
Cause and Transmission
The specific cause of IBD is not known, but the presence of inclusions in multiple tissues is what is currently used to make a
diagnosis. Costs can be a limiting factor in these diagnostics. Depending on the number of tissues submitted, tissue
biopsies from living snakes generally can be evaluated for less than $200, but note this doesn’t include the cost of taking the
biopsies. Submitting a blood film to a clinical pathologist to determine if inclusions are present is relatively inexpensive, but
there are limits on what this test will reveal. Full necropsies on dead snakes may cost $300 to $500 per case.
Although evidence supports a virus in the family Retroviridae, which includes the HIV and FIV viruses, as the causative
agent of IBD, the original retrovirus isolated from an IBD-infected snake was lost. In a more recent study, we isolated
several retroviruses from boa constrictors with IBD, and these isolates were partially characterized. Still, we do not know
whether one is the causative agent of IBD. These isolates need to be fully sequenced, so a molecular-based test that
permits testing of the tissues of infected snakes for the presence of the virus can be developed.
Like IBD’s cause, the disease’s exact route of transmission has not been determined, but direct contact is probably
involved. The common snake mite (Ophionyssus natricis) has been incriminated as a possible vector. Invariably, mites are
present in snake colonies experiencing an IBD outbreak. Thus preventing mites from entering a collection and eliminating
them in one are essential tasks. Eliminating mites from a collection is highly dependent upon the collection’s size. It’s also
possible the disease’s causative agent is passed on from mother to young in both egg-laying and live-bearing snakes.
IBD Prevention and Management
There is no easy template to follow to prevent IBD from entering a snake collection, or managing a breeding or pet collection
where the disease has been diagnosed. However, several approaches can reduce the risk of IBD entering a collection.
First and foremost, a solid preventative medicine program should be established. No such program is 100 percent effective
in all situations, so what we are talking about is risk reduction. Having a veterinarian knowledgeable about reptiles or
specializing in reptile medicine is all-important.
Snake- Savvy Vets
A veterinarian specializing in reptile medicine or knowledgeable about reptiles is one part of an effective preventative
medicine program for snakekeepers. Find lists of herp-friendly vets at ReptileChannel.com/VetList or through the
Association of Reptilian and Amphibian Veterinarians website: arav.org. Also essential is knowing the collection history of
soon-to-be-purchased snakes. This sounds simple, but actually it is not. Uncovering the history of the breeder’s collection is
often difficult to impossible. Snakes are bought and sold so easily on the Web and at shows, and new snake breeders start
up literally overnight. Plus the vast majority of snakes that die in a collection never undergo a necropsy or thorough work-up.
Breeders often don’t provide information on all diseases and pathogens seen in their collections over time. Every collection
inevitably has animals that do not do well and die of various problems. No collection is pathogen-free. So buyer beware, and
do your best to select animals from well-established, recognized breeders rather than purchasing animals because they are
selling for a very good price.
Quarantining new animals is essential, too. I recommend a quarantine period of at least 90 days. I have quarantined some
new animals up to six months. Ideally, quarantined animals should be in a building separate from your main collection. A
true quarantine is when all new animals enter the quarantine facility on the same day and leave on the same day.
Blood samples are the easiest tissue sample to collect, and films can be checked for the presence of IBD inclusions in cells.
If snakekeepers have the financial resources, biopsies can be obtained from a snake’s tonsils, liver and kidneys. This
certainly is not practical to do in all situations, but such before-death diagnostics improve the owner’s ability to identify an
infected animal. In the end, the cost of such quarantine programs and the use of these diagnostics depend on either the
money snakekeepers have to spend or the importance they attach to such preventative medicine programs. You can lead a
horse to water, but you sure can’t make it drink.
Finally, obviously ill snakes should never be entered into the established collection. Only well-feeding animals in excellent
condition should be added after the quarantine period is over. And make sure none are mite-infested. Many other things can
be done within the context of a preventative medicine program, but that topic is for another article to address. "
